InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wee2

Summary

InnateDB Protein

IDBP-139001.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wee2

Protein Name

WEE1 homolog 2 (S. pombe)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038754

InnateDB Gene

IDBG-138999 (Wee2)

Protein Structure

UniProt Annotation

Function

Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. {ECO:0000269PubMed:16169490, ECO:0000269PubMed:20083600, ECO:0000269PubMed:21454751}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Localizes mainly in the nucleus. Exported from the nucleus to the cytoplasm before germinal vesicle breakdown (GVBD), allowing meiosis resumption.

Disease Associations

Tissue Specificity

Ovary-specific. {ECO:0000269PubMed:16169490}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0007143	female meiotic division
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035038	female pronucleus assembly
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0060631	regulation of meiosis I
GO:1900194	negative regulation of oocyte maturation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome

Protein Structure and Domains

PDB ID

MGI:3027899

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017164 Wee1-like protein kinase
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

PIRSF037281

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References