Version 5.4
Mus musculus Protein: Tcte3
Summary
InnateDB Protein IDBP-139043.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcte3
Protein Name t-complex-associated testis expressed 3
Synonyms D17Leh117c; LC2; Tcte-3; Tctex-2; Tctex-4; Tctex2; Tctex4;
Species Mus musculus
Ensembl Protein ENSMUSP00000095010
InnateDB Gene IDBG-249254 (Tcte3)
Protein Structure
UniProt Annotation
Function May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000305PubMed:7601308}. Cytoplasmic granule {ECO:0000269PubMed:7601308}. Membrane {ECO:0000269PubMed:7601308}; Peripheral membrane protein {ECO:0000269PubMed:7601308}. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis.
Disease Associations Note=Could be involved in transmission ratio distortion (trd) in mouse t-haplotype which causes male sterility.
Tissue Specificity Expressed in testis (at protein level). Expressed at the pachyten stage of the first meiotic division and in later haploid spermatogenic stages. {ECO:0000269PubMed:11278908, ECO:0000269PubMed:12849985, ECO:0000269PubMed:1718647, ECO:0000269PubMed:3653077, ECO:0000269PubMed:7601308}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0016020 membrane
GO:0030286 dynein complex
Protein Structure and Domains
PDB ID MGI:98642
InterPro IPR005334 Tctex-1
PFAM PF03645
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P11985
PhosphoSite PhosphoSite-P11985
TrEMBL
UniProt Splice Variant
Entrez Gene 21647
UniGene
RefSeq NP_932772
MGI ID
MGI Symbol Tcte3
OMIM
CCDS CCDS28409
HPRD
IMGT
EMBL AK006370 AY172988 BC061136 BC131981 BC131983 M26332 U21673 U21674
GenPept AAA40413 AAA81010 AAA81011 AAH61136 AAI31982 AAI31984 AAO34134 BAB24552

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca