InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tas2r108

Summary

InnateDB Protein

IDBP-139155.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tas2r108

Protein Name

taste receptor, type 2, member 108

Synonyms

mGR08; mt2r8; T2R108; T2r8; Tas2r4; Tas2r8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044089

InnateDB Gene

IDBG-139153 (Tas2r108)

Protein Structure

UniProt Annotation

Function

Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell projection, cilium membrane. Note=In airway epithelial cells, localizes to motile cilia. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed in 15% taste bud cells in circumvallate and foliate papillae but only in 2% in fungiform papillae.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008527	taste receptor activity
GO:0033038	bitter taste receptor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007585	respiratory gaseous exchange
GO:0050909	sensory perception of taste