InnateDB Protein
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IDBP-139178.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ube2s
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Protein Name
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ubiquitin-conjugating enzyme E2S
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Synonyms
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0910001J09Rik; 6720465F12Rik; AA409170; E2-EPF;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000078459
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InnateDB Gene
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IDBG-139176 (Ube2s)
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Protein Structure
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Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
40 [view]
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Molecular Function |
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Biological Process |
GO:0010458
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exit from mitosis
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GO:0010994
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free ubiquitin chain polymerization
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0035519
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protein K29-linked ubiquitination
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GO:0044314
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protein K27-linked ubiquitination
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GO:0051488
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activation of anaphase-promoting complex activity
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GO:0070534
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protein K63-linked ubiquitination
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GO:0070979
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protein K11-linked ubiquitination
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GO:0085020
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protein K6-linked ubiquitination
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Cellular Component |
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PDB ID |
MGI:1925141
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q921J4
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PhosphoSite |
PhosphoSite-Q921J4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
77891
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UniGene |
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RefSeq |
NP_598538
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MGI ID |
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MGI Symbol |
Ube2s
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OMIM |
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CCDS |
CCDS39743
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HPRD |
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IMGT |
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EMBL |
AK003078
AK017648
AK146276
AK154026
AK154067
BC012255
BC030171
BC083323
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GenPept |
AAH12255
AAH30171
AAH83323
BAC25019
BAC25523
BAE27035
BAE32323
BAE32353
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