InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2s

Summary

InnateDB Protein

IDBP-139178.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2s

Protein Name

ubiquitin-conjugating enzyme E2S

Synonyms

0910001J09Rik; 6720465F12Rik; AA409170; E2-EPF;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078459

InnateDB Gene

IDBG-139176 (Ube2s)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0010458	exit from mitosis
GO:0010994	free ubiquitin chain polymerization
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0035519	protein K29-linked ubiquitination
GO:0044314	protein K27-linked ubiquitination
GO:0051488	activation of anaphase-promoting complex activity
GO:0070534	protein K63-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination
GO:0085020	protein K6-linked ubiquitination