Version 5.4
Mus musculus Protein: Thap7
Summary
InnateDB Protein IDBP-139262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thap7
Protein Name THAP domain containing 7
Synonyms 1810004B07Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000097701
InnateDB Gene IDBG-139258 (Thap7)
Protein Structure
UniProt Annotation
Function Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005694 chromosome
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:1916259
InterPro IPR006612 Zinc finger, C2CH-type
PFAM PF05485
PRINTS
PIRSF
SMART SM00692
SM00980
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VCZ3
PhosphoSite PhosphoSite-
TrEMBL D3YV14
UniProt Splice Variant
Entrez Gene 69009
UniGene Mm.10174
RefSeq NP_081185
MGI ID
MGI Symbol Thap7
OMIM
CCDS CCDS28004
HPRD
IMGT
EMBL AC113006 BC018221
GenPept AAH18221

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca