InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl21a

Summary

InnateDB Protein

IDBP-139353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl21a

Protein Name

chemokine (C-C motif) ligand 21A (serine)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092732

InnateDB Gene

IDBG-707736 (Ccl21a)

Protein Structure

UniProt Annotation

Function

Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T- cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs.

Subcellular Localization

Secreted.

Disease Associations

Note=Mice carrying an autosomal recessive mutation designated paucity of lymph node T-cells (plt) show dramatically reduced numbers of T-cells in lymph nodes, Peyer patches, and the white pulp of the spleen. Plt seems to correspond to Scya21b.

Tissue Specificity

Expressed strongly in lung, spleen, thymus, peripheral and mesentric lymph nodes. Also expressed in the testis, kidney, liver, and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity
GO:0031732	CCR7 chemokine receptor binding

Biological Process

GO:0001768	establishment of T cell polarity
GO:0001771	immunological synapse formation
GO:0001954	positive regulation of cell-matrix adhesion
GO:0002407	dendritic cell chemotaxis
GO:0002606	positive regulation of dendritic cell antigen processing and presentation
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0010560	positive regulation of glycoprotein biosynthetic process
GO:0010759	positive regulation of macrophage chemotaxis
GO:0030838	positive regulation of actin filament polymerization
GO:0031274	positive regulation of pseudopodium assembly
GO:0031295	T cell costimulation
GO:0031529	ruffle organization
GO:0032862	activation of Rho GTPase activity
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0034695	response to prostaglandin E
GO:0035759	mesangial cell-matrix adhesion
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045860	positive regulation of protein kinase activity
GO:0046330	positive regulation of JNK cascade
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048469	cell maturation
GO:0048535	lymph node development
GO:0050921	positive regulation of chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051491	positive regulation of filopodium assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090023	positive regulation of neutrophil chemotaxis
GO:0097026	dendritic cell dendrite assembly
GO:2000107	negative regulation of leukocyte apoptotic process
GO:2000147	positive regulation of cell motility
GO:2000529	positive regulation of myeloid dendritic cell chemotaxis
GO:2000548	negative regulation of dendritic cell dendrite assembly