InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pde4a

Summary

InnateDB Protein

IDBP-139360.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pde4a

Protein Name

phosphodiesterase 4A, cAMP specific

Synonyms

D9Ertd60e; Dpde2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003395

InnateDB Gene

IDBG-139354 (Pde4a)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0007608	sensory perception of smell
GO:0010738	regulation of protein kinase A signaling
GO:0035690	cellular response to drug
GO:0043949	regulation of cAMP-mediated signaling

Cellular Component

GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:99558

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt