InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lmbrd1

Summary

InnateDB Protein

IDBP-139363.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmbrd1

Protein Name

LMBR1 domain containing 1

Synonyms

0910001K20Rik; AV347960;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000092672

InnateDB Gene

IDBG-139361 (Lmbrd1)

Protein Structure

UniProt Annotation

Function

Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005158	insulin receptor binding
GO:0031419	cobalamin binding

Biological Process

GO:0038016	insulin receptor internalization
GO:0046325	negative regulation of glucose import
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0051898	negative regulation of protein kinase B signaling

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0045334	clathrin-coated endocytic vesicle