InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srpk2

Summary

InnateDB Protein

IDBP-139591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srpk2

Protein Name

serine/arginine-rich protein specific kinase 2

Synonyms

AW226533; AW492537; AW547358; mSRPK2; Wbp6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085734

InnateDB Gene

IDBG-139589 (Srpk2)

Protein Structure

UniProt Annotation

Function

Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up- regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. {ECO:0000269PubMed:19592491, ECO:0000269PubMed:9446799}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9446799}. Nucleus {ECO:0000269PubMed:9446799}. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testes, lung and brain. {ECO:0000269PubMed:9446799}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 173 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	173 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0044822	poly(A) RNA binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0001525	angiogenesis
GO:0006468	protein phosphorylation
GO:0008284	positive regulation of cell proliferation
GO:0008380	RNA splicing
GO:0010628	positive regulation of gene expression
GO:0030154	cell differentiation
GO:0035063	nuclear speck organization
GO:0035556	intracellular signal transduction
GO:0043525	positive regulation of neuron apoptotic process
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045787	positive regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1201408

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt