Version 5.4
Mus musculus Protein: Rnf185
Summary
InnateDB Protein IDBP-139605.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf185
Protein Name ring finger protein 185
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000067053
InnateDB Gene IDBG-139601 (Rnf185)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006914 autophagy
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005741 mitochondrial outer membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1922078
InterPro IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YT2
PhosphoSite PhosphoSite-Q91YT2
TrEMBL
UniProt Splice Variant
Entrez Gene 193670
UniGene Mm.406576
RefSeq NP_663330
MGI ID
MGI Symbol Rnf185
OMIM
CCDS CCDS24361
HPRD
IMGT
EMBL AK034108 AK052436 AK053358 AK075756 AK077638 AK149640 AK165895 AK167455 AK168904 BC014812
GenPept AAH14812 BAC28589 BAC34989 BAC35361 BAC35934 BAC36918 BAE29001 BAE38444 BAE39541 BAE40718

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca