InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snx6

Summary

InnateDB Protein

IDBP-139635.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snx6

Protein Name

sorting nexin 6

Synonyms

2010006G21Rik; 2610032J07Rik; 2810425K19Rik; AU018928; C85963;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005798

InnateDB Gene

IDBG-139633 (Snx6)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. Plays a role in retrograde protein transport from endosomes to the trans-Golgi network. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. May contribute to transcription regulation (By similarity). Promotes lysosomal degradation of CDKN1B. {ECO:0000250, ECO:0000269PubMed:20228253}.

Subcellular Localization

Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000269PubMed:20228253}; Peripheral membrane protein {ECO:0000269PubMed:20228253}; Cytoplasmic side {ECO:0000269PubMed:20228253}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes. Only a minor proportion is seen in the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0034713	type I transforming growth factor beta receptor binding
GO:0035091	phosphatidylinositol binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006886	intracellular protein transport
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0042147	retrograde transport, endosome to Golgi
GO:0045892	negative regulation of transcription, DNA-templated