InnateDB Protein
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IDBP-139643.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atg4d
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Protein Name
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autophagy-related 4D (yeast)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000068450
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InnateDB Gene
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IDBG-139641 (Atg4d)
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Protein Structure
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Function |
Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). {ECO:0000250}.Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cysteine protease ATG4D: Cytoplasm {ECO:0000250}.Cysteine protease ATG4D, mitochondrial: Cytoplasm. Mitochondrion matrix {ECO:0000250}. Note=Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004197
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cysteine-type endopeptidase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2444308
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InterPro |
IPR005078
Peptidase C54
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PFAM |
PF03416
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BGV9
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PhosphoSite |
PhosphoSite-Q8BGV9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
235040
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UniGene |
Mm.440165
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RefSeq |
NP_705811
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MGI ID |
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MGI Symbol |
Atg4d
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OMIM |
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CCDS |
CCDS22899
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HPRD |
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IMGT |
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EMBL |
AJ312333
AK036571
AK081002
AK081605
BC030861
BC069851
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GenPept |
AAH30861
AAH69851
BAC29484
BAC38110
BAC38269
CAC85952
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