InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dll1

Summary

InnateDB Protein

IDBP-139655.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dll1

Protein Name

delta-like 1 (Drosophila)

Synonyms

Delta1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014917

InnateDB Gene

IDBG-139653 (Dll1)

Protein Structure

UniProt Annotation

Function

May be involved in cell-to-cell communication in mammalian embryos. May have a role in cellular interactions underlying somitogenesis and development of the nervous system.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001756	somitogenesis
GO:0001757	somite specification
GO:0001947	heart looping
GO:0007154	cell communication
GO:0007219	Notch signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0007386	compartment pattern specification
GO:0007399	nervous system development
GO:0009887	organ morphogenesis
GO:0009912	auditory receptor cell fate commitment
GO:0032693	negative regulation of interleukin-10 production
GO:0042472	inner ear morphogenesis
GO:0042475	odontogenesis of dentin-containing tooth
GO:0042491	auditory receptor cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045608	negative regulation of auditory receptor cell differentiation
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048839	inner ear development
GO:0050767	regulation of neurogenesis
GO:0061314	Notch signaling involved in heart development
GO:0070986	left/right axis specification
GO:0072014	proximal tubule development
GO:0072070	loop of Henle development
GO:0097150	neuronal stem cell maintenance

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

MGI:104659

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001774 Delta/Serrate/lag-2 (DSL) protein
IPR001881 EGF-like calcium-binding domain
IPR011651 Notch ligand, N-terminal

PFAM

PF00008
PF01414
PF07645
PF07657

PRINTS

PIRSF

SMART

SM00181
SM00051
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61483