Version 5.4
Mus musculus Protein: Zbtb33
Summary
InnateDB Protein IDBP-139680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zbtb33
Protein Name zinc finger and BTB domain containing 33
Synonyms AW260253; E130014G12Rik; Kaiso; Znf-kaiso;
Species Mus musculus
Ensembl Protein ENSMUSP00000049983
InnateDB Gene IDBG-139678 (Zbtb33)
Protein Structure
UniProt Annotation
Function Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3'. May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. {ECO:0000269PubMed:15138284, ECO:0000269PubMed:15282317, ECO:0000269PubMed:15564377, ECO:0000269PubMed:15817151}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10207085, ECO:0000269PubMed:15282317, ECO:0000269PubMed:15564377}.
Disease Associations
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, neuromuscular junctions, skeletal muscle, spleen and testis. {ECO:0000269PubMed:10207085, ECO:0000269PubMed:15282317}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1927290
InterPro IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PF00651
PRINTS
PIRSF
SMART SM00225
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BN78
PhosphoSite PhosphoSite-Q8BN78
TrEMBL A2A3Z3
UniProt Splice Variant
Entrez Gene 56805
UniGene Mm.413943
RefSeq NP_064652
MGI ID
MGI Symbol Zbtb33
OMIM
CCDS CCDS30088
HPRD
IMGT
EMBL AF097416 AK087417 AK089423 AL512346 BC138647 BC138648 CH466570
GenPept AAD20989 AAI38648 AAI38649 BAC39866 BAC40875 EDL29007

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca