InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epb4.1l2

Summary

InnateDB Protein

IDBP-139707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epb4.1l2

Protein Name

erythrocyte protein band 4.1-like 2

Synonyms

4.1G; AW555191; D10Ertd398e; Epb41l2; NBL2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055122

InnateDB Gene

IDBG-139703 (Epb4.1l2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0030507	spectrin binding
GO:0042731	PH domain binding

Biological Process

GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0030866	cortical actin cytoskeleton organization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0015629	actin cytoskeleton
GO:0019898	extrinsic component of membrane
GO:0030054	cell junction
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:103009

InterPro

IPR000299 FERM domain
IPR000798 Ezrin/radixin/moesin like
IPR007477 SAB domain
IPR008379 Band 4.1, C-terminal
IPR014847 FERM adjacent (FA)
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR021187 Band 4.1 protein
IPR029071 Ubiquitin-related domain

PFAM

PF04382
PF05902
PF08736
PF09379
PF09380
PF00373

PRINTS

PR00661
PR00935

PIRSF

PIRSF002304

SMART

SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References