InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp580

Summary

InnateDB Protein

IDBP-139788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp580

Protein Name

zinc finger protein 580

Synonyms

1500015O20Rik; AI838225; Znf580;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065861

InnateDB Gene

IDBG-139786 (Zfp580)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Colocalized with SMAD2 in the nucleus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0010595	positive regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0032757	positive regulation of interleukin-8 production
GO:0070301	cellular response to hydrogen peroxide