Version 5.4
Mus musculus Protein: Psmb1
Summary
InnateDB Protein IDBP-139868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmb1
Protein Name proteasome (prosome, macropain) subunit, beta type 1
Synonyms AA409053; C81484; Lmpc5;
Species Mus musculus
Ensembl Protein ENSMUSP00000014913
InnateDB Gene IDBG-139866 (Psmb1)
Protein Structure
UniProt Annotation
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. {ECO:0000269PubMed:22341445}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Detected in liver (at protein level). {ECO:0000269PubMed:22341445}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 95 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 95 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:104884
InterPro IPR001353 Proteasome, subunit alpha/beta
IPR029055 Nucleophile aminohydrolases, N-terminal
PFAM PF00227
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O09061
PhosphoSite PhosphoSite-O09061
TrEMBL Q6RI64
UniProt Splice Variant
Entrez Gene 19170
UniGene Mm.398196
RefSeq NP_035315
MGI ID 3UNH
MGI Symbol Psmb1
OMIM
CCDS CCDS28411
HPRD
IMGT
EMBL AK077520 AK132161 AK167647 AY497019 BC018351 CH466630 U60824 X80686
GenPept AAB37251 AAH18351 AAR30867 BAC36841 BAE21005 BAE39698 CAA56701 CAA56702 EDL20463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca