InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Inpp5j

Summary

InnateDB Protein

IDBP-139888.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Inpp5j

Protein Name

inositol polyphosphate 5-phosphatase J

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046625

InnateDB Gene

IDBG-139886 (Inpp5j)

Protein Structure

UniProt Annotation

Function

Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12536145}. Note=Predominantly localized to membrane ruffles.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0017124	SH3 domain binding
GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

Biological Process

GO:0010977	negative regulation of neuron projection development
GO:0031115	negative regulation of microtubule polymerization
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0046856	phosphatidylinositol dephosphorylation