InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdkn2d

Summary

InnateDB Protein

IDBP-139900.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkn2d

Protein Name

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Synonyms

INK4d; p19; p19INK4d;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083561

InnateDB Gene

IDBG-738755 (Cdkn2d)

Protein Structure

UniProt Annotation

Function

Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269PubMed:7739547, ECO:0000269PubMed:7739548}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000731	DNA synthesis involved in DNA repair
GO:0006916	anti-apoptosis
GO:0007050	cell cycle arrest
GO:0007605	sensory perception of sound
GO:0008285	negative regulation of cell proliferation
GO:0009411	response to UV
GO:0016310	phosphorylation
GO:0030308	negative regulation of cell growth
GO:0032526	response to retinoic acid
GO:0033280	response to vitamin D
GO:0042326	negative regulation of phosphorylation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048102	autophagic cell death
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage