InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc44a2

Summary

InnateDB Protein

IDBP-140027.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc44a2

Protein Name

solute carrier family 44, member 2

Synonyms

1110028E10Rik; CTL2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034697

InnateDB Gene

IDBG-140023 (Slc44a2)

Protein Structure

UniProt Annotation

Function

Choline transporter. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in lung, colon, inner ear and spleen (at protein level). Progressively lower levels in brain, tongue, liver and kidney (at protein level). In the kidney, prominent expression in glomeruli in the lining of Bowman's capsule and on the mesangial cells adjacent to the vessels within the glomerulus (at protein level). Strongly expressed on the membranes of splenocytes and in lung parenchyme (at protein level). Isoform 1 is expressed at higher levels than isoform 2 in colon, heart, kidney, lung, cochlea, tongue and muscle, as well as in the inner ear. Isoform 2 is predominant in brain, liver and spleen. {ECO:0000269PubMed:20665236}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0007165	signal transduction
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

Cellular Component

GO:0005765	lysosomal membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1915932

InterPro

IPR007603 Choline transporter-like

PFAM

PF04515

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BY89

PhosphoSite

PhosphoSite-Q8BY89

TrEMBL

UniProt Splice Variant

Entrez Gene

68682

UniGene

Mm.487147

RefSeq

NP_690021

MGI ID

MGI Symbol

Slc44a2

OMIM

CCDS

CCDS22903

HPRD

IMGT

EMBL

AK041533 AK048648 BC031535

GenPept

AAH31535 BAC30976 BAC33409