InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klhl7

Summary

InnateDB Protein

IDBP-140079.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klhl7

Protein Name

kelch-like 7 (Drosophila)

Synonyms

2700038B03Rik; D5Ertd363e; SBBI26;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030841

InnateDB Gene

IDBG-140077 (Klhl7)

Protein Structure

UniProt Annotation

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0016567

protein ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0031463	Cul3-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:1196453

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt