InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptp4a1

Summary

InnateDB Protein

IDBP-140091.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptp4a1

Protein Name

protein tyrosine phosphatase 4a1

Synonyms

AA415290; AU019864; C130021B01; Prl-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027232

InnateDB Gene

IDBG-140089 (Ptp4a1)

Protein Structure

UniProt Annotation

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10747914}. Early endosome {ECO:0000269PubMed:10747914}. Endoplasmic reticulum {ECO:0000269PubMed:10747914}. Cytoplasm {ECO:0000269PubMed:10747914}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:10747914}. Note=And mitotic spindle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0004727	prenylated protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007049	cell cycle
GO:0007275	multicellular organismal development
GO:0016311	dephosphorylation
GO:0030335	positive regulation of cell migration
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005819	spindle
GO:0005886	plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1277096

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt