InnateDB Protein
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IDBP-140097.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ptf1a
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Protein Name
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pancreas specific transcription factor, 1a
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Synonyms
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bHLHa29; PTF1-p48; PTF1p48;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000028068
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InnateDB Gene
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IDBG-140095 (Ptf1a)
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Protein Structure
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Function |
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. {ECO:0000269PubMed:11562365, ECO:0000269PubMed:12185368, ECO:0000269PubMed:15543146, ECO:0000269PubMed:17075007, ECO:0000269PubMed:9851981}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=In the cytoplasm loses its ability to form the PTF1 complex.
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Disease Associations |
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Tissue Specificity |
Expressed in precursors of pancreatic islets, acini and ducts. {ECO:0000269PubMed:9851981}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0001077
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RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
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GO:0003677
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DNA binding
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GO:0003682
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chromatin binding
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GO:0005515
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protein binding
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GO:0043565
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sequence-specific DNA binding
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GO:0046983
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protein dimerization activity
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GO:0070888
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E-box binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1328312
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InterPro |
IPR011598
Myc-type, basic helix-loop-helix (bHLH) domain
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PFAM |
PF00010
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PRINTS |
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PIRSF |
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SMART |
SM00353
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QX98
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PhosphoSite |
PhosphoSite-Q9QX98
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TrEMBL |
A2ATA7
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UniProt Splice Variant |
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Entrez Gene |
19213
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UniGene |
Mm.69647
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RefSeq |
NP_061279
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MGI ID |
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MGI Symbol |
Ptf1a
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OMIM |
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CCDS |
CCDS15715
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HPRD |
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IMGT |
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EMBL |
AB035674
AB035675
AF298116
AJ252156
AK007922
BC132505
BC138507
CH466542
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GenPept |
AAG31604
AAI32506
AAI38508
BAA88247
BAA88249
BAE43208
CAB65273
EDL08116
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