InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il21

Summary

InnateDB Protein

IDBP-140269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il21

Protein Name

interleukin 21

Synonyms

IL-21;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029273

InnateDB Gene

IDBG-140267 (Il21)

Protein Structure

UniProt Annotation

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T- cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269PubMed:11970879, ECO:0000269PubMed:12893770, ECO:0000269PubMed:15100251}.

Subcellular Localization

Secreted {ECO:0000269PubMed:11970879}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	0
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005134	interleukin-2 receptor binding

Biological Process

GO:0001783	B cell apoptotic process
GO:0002729	positive regulation of natural killer cell cytokine production
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0030890	positive regulation of B cell proliferation
GO:0032733	positive regulation of interleukin-10 production
GO:0032740	positive regulation of interleukin-17 production
GO:0032825	positive regulation of natural killer cell differentiation
GO:0042102	positive regulation of T cell proliferation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045579	positive regulation of B cell differentiation
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048469	cell maturation