InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp2r3c

Summary

InnateDB Protein

IDBP-140348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp2r3c

Protein Name

protein phosphatase 2, regulatory subunit B'', gamma

Synonyms

4930511A21Rik; 5730412A08Rik; G4-1; G5pr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021410

InnateDB Gene

IDBG-140346 (Ppp2r3c)

Protein Structure

UniProt Annotation

Function

May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells. {ECO:0000269PubMed:12167160, ECO:0000269PubMed:16129705, ECO:0000269PubMed:16343422}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12167160}. Cytoplasm {ECO:0000269PubMed:12167160}. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.

Disease Associations

Tissue Specificity

Expressed in all tissues tested including heart, brain, spleen, thymus, lung, liver, kidney and testis. {ECO:0000269PubMed:12167160}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001782	B cell homeostasis
GO:0002759	regulation of antimicrobial humoral response
GO:0032147	activation of protein kinase activity
GO:0043029	T cell homeostasis
GO:0045579	positive regulation of B cell differentiation
GO:0048536	spleen development
GO:0050864	regulation of B cell activation
GO:0051900	regulation of mitochondrial depolarization