Mus musculus Protein: L3mbtl3
Summary
InnateDB Protein IDBP-140443.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol L3mbtl3
Protein Name l(3)mbt-like 3 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000037619
InnateDB Gene IDBG-140441 (L3mbtl3)
Protein Structure
UniProt Annotation
Function Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Required for normal maturation of myeloid progenitor cells. {ECO:0000250, ECO:0000269PubMed:15889154}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15889154}.
Disease Associations
Tissue Specificity Detected in hematopoietic progenitor cells in fetal liver. Detected in adult bone marrow, heart, brain, spleen, lung, liver, kidney and testis. {ECO:0000269PubMed:15889154}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
GO:0030099 myeloid cell differentiation
GO:0030225 macrophage differentiation
GO:0030851 granulocyte differentiation
GO:0043249 erythrocyte maturation
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2143628
InterPro IPR001660 Sterile alpha motif domain
IPR004092 Mbt repeat
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
PFAM PF02820
PF07647
PF00536
PRINTS
PIRSF
SMART SM00454
SM00561
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BLB7
PhosphoSite PhosphoSite-Q8BLB7
TrEMBL Q8BMN8
UniProt Splice Variant
Entrez Gene 237339
UniGene Mm.338439
RefSeq XP_006512794
MGI ID
MGI Symbol L3mbtl3
OMIM
CCDS CCDS23756
HPRD
IMGT
EMBL AK030412 AK031398 AK045667 AK129443 BC082309 BC085192
GenPept AAH82309 AAH85192 BAC26951 BAC27386 BAC32449 BAC98253