InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgf2

Summary

InnateDB Protein

IDBP-140466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgf2

Protein Name

fibroblast growth factor 2

Synonyms

bFGF; Fgf-2; Fgfb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037694

InnateDB Gene

IDBG-140464 (Fgf2)

Protein Structure

UniProt Annotation

Function

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}. Nucleus {ECO:0000250}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0017134	fibroblast growth factor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042056	chemoattractant activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0000189	MAPK import into nucleus
GO:0001525	angiogenesis
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001759	organ induction
GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006700	C21-steroid hormone biosynthetic process
GO:0007568	aging
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009790	embryo development
GO:0009792	embryo development ending in birth or egg hatching
GO:0010001	glial cell differentiation
GO:0010595	positive regulation of endothelial cell migration
GO:0010628	positive regulation of gene expression
GO:0010764	negative regulation of fibroblast migration
GO:0010863	positive regulation of phospholipase C activity
GO:0021762	substantia nigra development
GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
GO:0030214	hyaluronan catabolic process
GO:0030308	negative regulation of cell growth
GO:0030324	lung development
GO:0032958	inositol phosphate biosynthetic process
GO:0042060	wound healing
GO:0042660	positive regulation of cell fate specification
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045597	positive regulation of cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046668	regulation of retinal cell programmed cell death
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0048678	response to axon injury
GO:0048864	stem cell development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050918	positive chemotaxis
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051726	regulation of cell cycle
GO:0051781	positive regulation of cell division
GO:0051897	positive regulation of protein kinase B signaling
GO:0060038	cardiac muscle cell proliferation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060128	corticotropin hormone secreting cell differentiation
GO:0060129	thyroid-stimulating hormone-secreting cell differentiation
GO:0060548	negative regulation of cell death
GO:0060591	chondroblast differentiation
GO:0060644	mammary gland epithelial cell differentiation
GO:0060978	angiogenesis involved in coronary vascular morphogenesis
GO:0061045	negative regulation of wound healing
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090263	positive regulation of canonical Wnt signaling pathway