InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mal2

Summary

InnateDB Protein

IDBP-140576.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mal2

Protein Name

mal, T-cell differentiation protein 2

Synonyms

AI461653;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025356

InnateDB Gene

IDBG-140574 (Mal2)

Protein Structure

UniProt Annotation

Function

Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome