InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nfkbia

Summary

InnateDB Protein

IDBP-140710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nfkbia

Protein Name

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Synonyms

AI462015; Nfkbi;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021413

InnateDB Gene

IDBG-140708 (Nfkbia)

Protein Structure

UniProt Annotation

Function

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269PubMed:10097128, ECO:0000269PubMed:9990853}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal and reproductive tract.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 148 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	38 [view]
Protein-DNA	16 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	148 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008139	nuclear localization sequence binding
GO:0019899	enzyme binding
GO:0031072	heat shock protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding
GO:0051059	NF-kappaB binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0007253	cytoplasmic sequestering of NF-kappaB
GO:0010468	regulation of gene expression
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010875	positive regulation of cholesterol efflux
GO:0010888	negative regulation of lipid storage
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032495	response to muramyl dipeptide
GO:0032496	response to lipopolysaccharide
GO:0034142	toll-like receptor 4 signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042994	cytoplasmic sequestering of transcription factor
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)
GO:0045638	negative regulation of myeloid cell differentiation
GO:0045746	negative regulation of Notch signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway