Version 5.4
Mus musculus Protein: Insm2
Summary
InnateDB Protein IDBP-140781.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Insm2
Protein Name insulinoma-associated 2
Synonyms Mlt1;
Species Mus musculus
Ensembl Protein ENSMUSP00000061046
InnateDB Gene IDBG-140779 (Insm2)
Protein Structure
UniProt Annotation
Function May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. {ECO:0000269PubMed:11221845}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:21343251}. Nucleus {ECO:0000269PubMed:21343251}.
Disease Associations
Tissue Specificity Expressed in spleen, stomach, liver, kidney and testis. In the pancreas, expressed in islet cells, including insulin-producing beta-cells, but not in acinar cells (at protein level). In the brain, expressed in the neuronal cells of the cerebral cortex, the Purkinje cells of the cerebellum and the hippocampal region including CA1 and CA3 (at protein level). {ECO:0000269PubMed:11221845, ECO:0000269PubMed:21343251}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1930787
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JMC2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 56856
UniGene Mm.114886
RefSeq NP_064683
MGI ID
MGI Symbol Insm2
OMIM
CCDS CCDS25919
HPRD
IMGT
EMBL AB032418 AC158398
GenPept BAA92776

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca