Version 5.4
Mus musculus Protein: Il17rd
Summary
InnateDB Protein IDBP-140858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il17rd
Protein Name interleukin 17 receptor D
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036076
InnateDB Gene IDBG-140856 (Il17rd)
Protein Structure
UniProt Annotation
Function Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK (By similarity). Mediates JNK activation and may be involved in apoptosis. Might have a role in the early stages of fate specification of GnRH-secreting neurons. {ECO:0000250, ECO:0000269PubMed:12604616, ECO:0000269PubMed:15277532}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Associated with the Golgi apparatus and is partially translocated to the plasma membrane upon stimulation. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0007165 signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2159727
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003961 Fibronectin, type III
IPR007087 Zinc finger, C2H2
IPR013568 SEFIR
PFAM PF01582
PF13676
PF00041
PF01108
PF00096
PF08357
PRINTS
PIRSF
SMART SM00255
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8JZL1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 171463
UniGene Mm.206726
RefSeq NP_602319
MGI ID
MGI Symbol Il17rd
OMIM
CCDS CCDS26885
HPRD
IMGT
EMBL AF424804 AF459444 AF494209 AF494210 BC138629
GenPept AAI38630 AAL79530 AAM28441 AAM74078 AAM74079

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca