InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thoc2

Summary

InnateDB Protein

IDBP-140863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thoc2

Protein Name

THO complex 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044677

InnateDB Gene

IDBG-140859 (Thoc2)

Protein Structure

UniProt Annotation

Function

Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}. Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0001824	blastocyst development
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010468	regulation of gene expression
GO:0010793	regulation of mRNA export from nucleus
GO:0016973	poly(A)+ mRNA export from nucleus
GO:0017145	stem cell division
GO:0046784	intronless viral mRNA export from host nucleus