InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fat4

Summary

InnateDB Protein

IDBP-140993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fat4

Protein Name

FAT tumor suppressor homolog 4 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061836

InnateDB Gene

IDBG-140991 (Fat4)

Protein Structure

UniProt Annotation

Function

Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. {ECO:0000269PubMed:18604206, ECO:0000269PubMed:24056717}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In the kidney, localizes to primary cilia. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:16059920}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001736	establishment of planar polarity
GO:0001822	kidney development
GO:0003007	heart morphogenesis
GO:0007009	plasma membrane organization
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0021987	cerebral cortex development
GO:0022008	neurogenesis
GO:0035329	hippo signaling
GO:0043931	ossification involved in bone maturation
GO:0048565	digestive tract development
GO:0060122	inner ear receptor stereocilium organization
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:3045256

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR002126 Cadherin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR015919 Cadherin-like

PFAM

PF00008
PF00054
PF02210
PF07645
PF00028

PRINTS

PR00205

PIRSF

SMART

SM00181
SM00210
SM00282
SM00179
SM00112

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt