InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpv5

Summary

InnateDB Protein

IDBP-140996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpv5

Protein Name

transient receptor potential cation channel, subfamily V, member 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031901

InnateDB Gene

IDBG-140994 (Trpv5)

Protein Structure

UniProt Annotation

Function

Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:12660155}; Multi-pass membrane protein {ECO:0000269PubMed:12660155}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0051262	protein tetramerization
GO:0055085	transmembrane transport
GO:0060402	calcium ion transport into cytosol
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

MGI:2429764

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR005821 Ion transport domain
IPR008344 Transient receptor potential cation channel subfamily V member 5/6
IPR008346 Transient receptor potential cation channel subfamily V member 5
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF00520
PF11929
PF12796

PRINTS

PR01415
PR01765
PR01767

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt