Version 5.4
Mus musculus Protein: Prodh
Summary
InnateDB Protein IDBP-141020.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prodh
Protein Name proline dehydrogenase
Synonyms Pro-1; Pro1; Ym24d07;
Species Mus musculus
Ensembl Protein ENSMUSP00000003620
InnateDB Gene IDBG-141018 (Prodh)
Protein Structure
UniProt Annotation
Function Converts proline to delta-1-pyrroline-5-carboxylate.
Subcellular Localization Mitochondrion matrix.
Disease Associations Note=Pro/re mice that have a premature termination on Prodh are sluggish in their movement.
Tissue Specificity Expressed in liver, kidney, heart and to a lesser extent in brain, lung and muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004657 proline dehydrogenase activity
GO:0016597 amino acid binding
GO:0071949 FAD binding
Biological Process
GO:0006537 glutamate biosynthetic process
GO:0006562 proline catabolic process
GO:0010133 proline catabolic process to glutamate
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:97770
InterPro IPR002872 Proline dehydrogenase
IPR029041 FAD-linked oxidoreductase-like
PFAM PF01619
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WU79
PhosphoSite PhosphoSite-Q9WU79
TrEMBL F6XMC0
UniProt Splice Variant
Entrez Gene 19125
UniGene Mm.405088
RefSeq NP_035302
MGI ID
MGI Symbol Prodh
OMIM
CCDS CCDS37278
HPRD
IMGT
EMBL AC087064 AF120279 AK144068 BC125327 CH466521 U80020
GenPept AAD24776 AAF21467 AAI25328 BAE25683 EDK97501

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca