Version 5.4
Mus musculus Protein: Kel
Summary
InnateDB Protein IDBP-141094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kel
Protein Name Kell blood group
Synonyms CD238; Ece3;
Species Mus musculus
Ensembl Protein ENSMUSP00000031899
InnateDB Gene IDBG-141092 (Kel)
Protein Structure
UniProt Annotation
Function Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3 (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in spleen. Weaker expression in testis and heart. {ECO:0000269PubMed:11132157}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1346053
InterPro IPR008753 Peptidase M13, N-terminal domain
IPR018497 Peptidase M13, C-terminal domain
PFAM PF05649
PF01431
PRINTS PR00786
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EQF2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 23925
UniGene Mm.19958
RefSeq NP_115929
MGI ID
MGI Symbol Kel
OMIM
CCDS CCDS20055
HPRD
IMGT
EMBL AF252870 AF336378 AK028430 BC099961
GenPept AAG48572 AAH99961 AAM53407 BAC25947

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca