Mus musculus Protein: Fpr3 | |||||||
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Summary | |||||||
InnateDB Protein | IDBP-141099.6 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | Fpr3 | ||||||
Protein Name | formyl peptide receptor 3 | ||||||
Synonyms | ALX; Fpr-rs1; Fpr-s1; Fprl1; LXA4-R; Lxa4r; | ||||||
Species | Mus musculus | ||||||
Ensembl Protein | ENSMUSP00000093316 | ||||||
InnateDB Gene | IDBG-249348 (Fpr3) | ||||||
Protein Structure | |||||||
UniProt Annotation | |||||||
Function | Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states. {ECO:0000269PubMed:19387439}. | ||||||
Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||
Disease Associations | |||||||
Tissue Specificity | Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439). {ECO:0000269PubMed:19387439, ECO:0000269PubMed:19497865, ECO:0000269PubMed:9151906, ECO:0000269PubMed:9722950}. | ||||||
Comments | |||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||
PDB ID | MGI:1194495 | ||||||
InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR002234 Anaphylatoxin chemotactic receptor family IPR002258 DEZ orphan receptor IPR017452 GPCR, rhodopsin-like, 7TM |
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PFAM |
PF00001
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PRINTS |
PR00237
PR01104 PR01126 |
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PIRSF | |||||||
SMART | |||||||
TIGRFAMs | |||||||
Post-translational Modifications | |||||||
Modification | |||||||
Cross-References | |||||||
SwissProt | O08790 | ||||||
PhosphoSite | PhosphoSite- | ||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | 14294 | ||||||
UniGene | Mm.378918 | ||||||
RefSeq | |||||||
MGI ID | |||||||
MGI Symbol | Fpr3 | ||||||
OMIM | |||||||
CCDS | CCDS28420 | ||||||
HPRD | |||||||
IMGT | |||||||
EMBL | AF071179 U78299 | ||||||
GenPept | AAC34584 AAC53198 | ||||||