InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Peg3

Summary

InnateDB Protein

IDBP-141102.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Peg3

Protein Name

paternally expressed 3

Synonyms

AL022617; ASF-1; End4; Gcap4; mKIAA0287; Pw1; Zfp102;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050750

InnateDB Gene

IDBG-141100 (Peg3)

Protein Structure

UniProt Annotation

Function

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth. {ECO:0000269PubMed:10195900, ECO:0000269PubMed:10681424, ECO:0000269PubMed:11943780, ECO:0000269PubMed:9500555}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Brain, glial cells, neurons, skeletal muscle, uterus and placenta. In the placenta it found in all trophoblast cells. {ECO:0000269PubMed:11260267, ECO:0000269PubMed:11331620, ECO:0000269PubMed:8563758, ECO:0000269PubMed:8806818}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006915	apoptotic process
GO:0010468	regulation of gene expression
GO:0035264	multicellular organism growth
GO:0071514	genetic imprinting