Version 5.4
Mus musculus Protein: Intu
Summary
InnateDB Protein IDBP-141130.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Intu
Protein Name inturned planar cell polarity effector homolog (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000088725
InnateDB Gene IDBG-141126 (Intu)
Protein Structure
UniProt Annotation
Function Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. {ECO:0000269PubMed:20067783, ECO:0000269PubMed:21761479}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:20067783}. Cell surface {ECO:0000250}. Note=Enriched at the apical surface in ciliated cells.
Disease Associations
Tissue Specificity Widely expressed in E8.5 and E9.5 wild type embryos. Present in various adult organs (at protein level). {ECO:0000269PubMed:20067783}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0008589 regulation of smoothened signaling pathway
GO:0010839 negative regulation of keratinocyte proliferation
GO:0021513 spinal cord dorsal/ventral patterning
GO:0030216 keratinocyte differentiation
GO:0031069 hair follicle morphogenesis
GO:0042384 cilium assembly
GO:0045880 positive regulation of smoothened signaling pathway
GO:0051782 negative regulation of cell division
GO:0060173 limb development
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0009986 cell surface
Protein Structure and Domains
PDB ID MGI:2443752
InterPro IPR001478 PDZ domain
PFAM PF00595
PF13180
PRINTS
PIRSF
SMART SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q059U7
PhosphoSite PhosphoSite-Q059U7
TrEMBL
UniProt Splice Variant
Entrez Gene 380614
UniGene Mm.487696
RefSeq NP_780724
MGI ID
MGI Symbol Intu
OMIM
CCDS
HPRD
IMGT
EMBL AC146980 AC163023 AK035092 AK040233 AK122485 BC125523 BC132387 CH466530
GenPept AAI25524 AAI32388 BAC28943 BAC30547 BAC65767 EDL35133

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca