Version 5.4
Mus musculus Protein: Deptor
Summary
InnateDB Protein IDBP-141162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Deptor
Protein Name DEP domain containing MTOR-interacting protein
Synonyms Depdc6;
Species Mus musculus
Ensembl Protein ENSMUSP00000094167
InnateDB Gene IDBG-141160 (Deptor)
Protein Structure
UniProt Annotation
Function Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006469 negative regulation of protein kinase activity
GO:0032007 negative regulation of TOR signaling
GO:0035556 intracellular signal transduction
GO:0045792 negative regulation of cell size
GO:2001236 regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID MGI:2146322
InterPro IPR000591 DEP domain
IPR001478 PDZ domain
PFAM PF00610
PF00595
PF13180
PRINTS
PIRSF
SMART SM00049
SM00228
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q570Y9
PhosphoSite PhosphoSite-Q570Y9
TrEMBL B2ZRS3
UniProt Splice Variant
Entrez Gene 97998
UniGene Mm.407064
RefSeq NP_663445
MGI ID
MGI Symbol Deptor
OMIM
CCDS CCDS27474
HPRD
IMGT
EMBL AK139888 AK145208 AK220300 EU681960 EU681961
GenPept ACD12867 ACD12868 BAD90225 BAE24172 BAE26298

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca