Version 5.4
Mus musculus Protein: Erc2
Summary
InnateDB Protein IDBP-141401.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Erc2
Protein Name ELKS/RAB6-interacting/CAST family member 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000087773
InnateDB Gene IDBG-141399 (Erc2)
Protein Structure
UniProt Annotation
Function Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:12163476}. Cell junction, synapse {ECO:0000269PubMed:12163476}. Cell junction, synapse, synaptosome {ECO:0000269PubMed:12163476}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12163476}. Note=Localized to the active zone of presynaptic density.
Disease Associations
Tissue Specificity Expressed throughout the central nervous system, including hippocampus, cortex, cerebellum and olfactory bulb. {ECO:0000269PubMed:12163476}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030054 cell junction
GO:0030426 growth cone
GO:0042734 presynaptic membrane
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:1098749
InterPro IPR009053 Prefoldin
IPR019323 CAZ complex, RIM-binding protein
PFAM PF10174
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PH08
PhosphoSite PhosphoSite-Q6PH08
TrEMBL
UniProt Splice Variant
Entrez Gene 238988
UniGene Mm.412779
RefSeq NP_808482
MGI ID
MGI Symbol Erc2
OMIM
CCDS CCDS26887
HPRD
IMGT
EMBL AK032385 AK122265 BC056760
GenPept AAH56760 BAC27848 BAC65547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca