Version 5.4
Mus musculus Protein: Mboat1
Summary
InnateDB Protein IDBP-141518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mboat1
Protein Name membrane bound O-acyltransferase domain containing 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000045441
InnateDB Gene IDBG-141516 (Mboat1)
Protein Structure
UniProt Annotation
Function Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidylserine (1-acyl-2- hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269PubMed:18287005}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269PubMed:18287005}.
Disease Associations
Tissue Specificity Highly expressed in stomach, epididymis, and colon. {ECO:0000269PubMed:18287005}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2387184
InterPro IPR004299 Membrane bound O-acyl transferase, MBOAT
PFAM PF03062
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BH98
PhosphoSite PhosphoSite-Q8BH98
TrEMBL Q5T1H3
UniProt Splice Variant
Entrez Gene 218121
UniGene Mm.89682
RefSeq NP_705774
MGI ID
MGI Symbol Mboat1
OMIM
CCDS CCDS26414
HPRD
IMGT
EMBL AB297382 AB305045 AK033388 AK146984 AL450321 AL645749 BC023845 BC024653 CH466561
GenPept AAH23845 AAH24653 BAC28261 BAE27587 BAF93901 BAG12121 CAI24381 CAI24382 CAI24665 CAI24667 EDL32389 EDL32390

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca