InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxa1

Summary

InnateDB Protein

IDBP-141539.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxa1

Protein Name

forkhead box A1

Synonyms

Hnf-3a; Hnf3a; Tcf-3a; Tcf3a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041118

InnateDB Gene

IDBG-141537 (Foxa1)

Protein Structure

UniProt Annotation

Function

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Plays a role in prostate morphogenesis and epithelial cell differentiation. FOXA1 and FOXA2 are essential for hepatic specification. FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung. FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding of glucocorticoid receptor/NR3C1 to the IL6 promoter. FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription. Inhibits NKX2-1-mediated transcription from the SFTPC promoter in lung epithel independently from DNA-binding. Involved in regulation of apoptosis. Involved in cell cycle regulation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates the GCG promoter. {ECO:0000250, ECO:0000269PubMed:10049364, ECO:0000269PubMed:11864602, ECO:0000269PubMed:15668254, ECO:0000269PubMed:15748903, ECO:0000269PubMed:15959514, ECO:0000269PubMed:15987773, ECO:0000269PubMed:17596284, ECO:0000269PubMed:19141476, ECO:0000269PubMed:19436110}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:15987773}.

Disease Associations

Tissue Specificity

Restricted mainly to endoderm-derived tissues (lung, liver, stomach, and small intestine). Expressed in the prostate. {ECO:0000269PubMed:15987773}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	2 [view]
Protein-DNA	23 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0010468	regulation of gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0021904	dorsal/ventral neural tube patterning
GO:0030324	lung development
GO:0032355	response to estradiol
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0035239	tube morphogenesis
GO:0042445	hormone metabolic process
GO:0042593	glucose homeostasis
GO:0045666	positive regulation of neuron differentiation
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048665	neuron fate specification
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726	regulation of cell cycle
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060738	epithelial-mesenchymal signaling involved in prostate gland development
GO:0060740	prostate gland epithelium morphogenesis
GO:0060741	prostate gland stromal morphogenesis
GO:0060743	epithelial cell maturation involved in prostate gland development
GO:0061448	connective tissue development