InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tln1

Summary

InnateDB Protein

IDBP-141553.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tln1

Protein Name

talin 1

Synonyms

Tln;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030187

InnateDB Gene

IDBG-141551 (Tln1)

Protein Structure

UniProt Annotation

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.

Subcellular Localization

Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000269PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269PubMed:21768292}. Note=Colocalizes with LAYN at the membrane ruffles (By similarity). Localized preferentially in focal adhesions than fibrillar adhesions. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005158	insulin receptor binding
GO:0005178	integrin binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0017166	vinculin binding
GO:0030274	LIM domain binding
GO:0032403	protein complex binding

Biological Process

GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0030866	cortical actin cytoskeleton organization

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0032587	ruffle membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1099832

InterPro

IPR000299 FERM domain
IPR002404 Insulin receptor substrate-1, PTB
IPR002558 I/LWEQ domain
IPR006077 Vinculin/alpha-catenin
IPR015009 Vinculin-binding site-containing domain
IPR015224 Talin, central
IPR018979 FERM, N-terminal
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR029071 Ubiquitin-related domain

PFAM