InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kank2

Summary

InnateDB Protein

IDBP-141593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kank2

Protein Name

KN motif and ankyrin repeat domains 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034717

InnateDB Gene

IDBG-141591 (Kank2)

Protein Structure

UniProt Annotation

Function

Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase- independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (By similarity). May be involved in promotion of cell proliferation. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in liver and skeletal muscle. {ECO:0000269PubMed:20720434}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0008285	negative regulation of cell proliferation
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0043069	negative regulation of programmed cell death
GO:0051497	negative regulation of stress fiber assembly
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle