Version 5.4
Mus musculus Protein: Clcn1
Summary
InnateDB Protein IDBP-141598.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clcn1
Protein Name chloride channel 1
Synonyms adr; Clc-1; Clc1; mto; myotonia; nmf355; SMCC1;
Species Mus musculus
Ensembl Protein ENSMUSP00000031894
InnateDB Gene IDBG-141596 (Clcn1)
Protein Structure
UniProt Annotation
Function Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Predominantly expressed in skeletal muscles.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0006821 chloride transport
GO:0019227 neuronal action potential propagation
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0042383 sarcolemma
Protein Structure and Domains
PDB ID MGI:88417
InterPro IPR000644 CBS domain
IPR001807 Chloride channel, voltage gated
IPR002243 Chloride channel ClC-1
IPR014743 Chloride channel, core
PFAM PF00571
PF00654
PRINTS PR00762
PR01112
PIRSF
SMART SM00116
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q64347
PhosphoSite PhosphoSite-Q64347
TrEMBL E9Q2N3
UniProt Splice Variant
Entrez Gene 12723
UniGene Mm.386757
RefSeq NP_038519
MGI ID
MGI Symbol Clcn1
OMIM
CCDS CCDS39471
HPRD
IMGT
EMBL AC153915 AK036735 BC114336 CH466533 X62895 X62896 X62897 Z95127 Z95128 Z95129 Z95130 Z95131 Z95132 Z95133 Z95134 Z95135 Z95136 Z95137 Z95138 Z95139 Z95140 Z95141 Z95142 Z95143 Z95144 Z95145 Z95146 Z95147 Z95148 Z95149
GenPept AAI14337 BAC29557 CAA44684 CAA44685 CAA44686 CAB08359 EDL13488

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca