InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf14

Summary

InnateDB Protein

IDBP-141609.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf14

Protein Name

ring finger protein 14

Synonyms

2310075C09Rik; 2610005D23Rik; AA986456; AU041447; D18Ertd188e; D7Bwg0165e; Triad2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072212

InnateDB Gene

IDBG-141607 (Rnf14)

Protein Structure

UniProt Annotation

Function

Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019787	small conjugating protein ligase activity
GO:0050681	androgen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008152	metabolic process
GO:0032355	response to estradiol
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060765	regulation of androgen receptor signaling pathway