InnateDB Protein
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IDBP-141612.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sh2d1a
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Protein Name
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SH2 domain protein 1A
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Synonyms
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Gm686; SAP;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000005839
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InnateDB Gene
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IDBG-141610 (Sh2d1a)
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Protein Structure
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Function |
Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. {ECO:0000269PubMed:16223723}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
T-cells.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
|
Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
23 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1328352
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InterPro |
IPR000980
SH2 domain
IPR017289
SH2 protein 1A
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PFAM |
PF00017
PF14633
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PRINTS |
PR00401
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PIRSF |
PIRSF037828
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SMART |
SM00252
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TIGRFAMs |
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Modification |
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SwissProt |
O88890
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PhosphoSite |
PhosphoSite-O88890
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TrEMBL |
Q544F1
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UniProt Splice Variant |
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Entrez Gene |
20400
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UniGene |
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RefSeq |
NP_035494
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MGI ID |
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MGI Symbol |
Sh2d1a
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OMIM |
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CCDS |
CCDS30099
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HPRD |
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IMGT |
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EMBL |
AF072903
AF097632
AF097633
AF154503
AF154504
AF154505
AK040076
AL831716
BC147367
BC147368
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GenPept |
AAC62629
AAC95998
AAC95999
AAF14526
AAI47368
AAI47369
BAC30506
CAM19525
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