InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sh2d1a

Summary

InnateDB Protein

IDBP-141612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh2d1a

Protein Name

SH2 domain protein 1A

Synonyms

Gm686; SAP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005839

InnateDB Gene

IDBG-141610 (Sh2d1a)

Protein Structure

UniProt Annotation

Function

Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. Mediates interaction between FYN and SLAMF1. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. {ECO:0000269PubMed:16223723}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

T-cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0006959	humoral immune response
GO:0006968	cellular defense response
GO:0007267	cell-cell signaling
GO:0009967	positive regulation of signal transduction
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity