InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnpda1

Summary

InnateDB Protein

IDBP-141671.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnpda1

Protein Name

glucosamine-6-phosphate deaminase 1

Synonyms

Gnp1; GNPDA; Gnpi; oscillin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000069081

InnateDB Gene

IDBG-141669 (Gnpda1)

Protein Structure

UniProt Annotation

Function

Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10481053}.

Disease Associations

Tissue Specificity

Widely expressed. Detected in brain, liver, kidney, muscle, ovary, testis, spermatids and spermatozoa. In spermatids, located close to the developing acrosome vesicle. In spermatozoa, found close to the acrosomal region. {ECO:0000269PubMed:10481053}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004342	glucosamine-6-phosphate deaminase activity
GO:0016787	hydrolase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006041	glucosamine metabolic process
GO:0006043	glucosamine catabolic process
GO:0006044	N-acetylglucosamine metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0007340	acrosome reaction
GO:0046370	fructose biosynthetic process