InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sec23a

Summary

InnateDB Protein

IDBP-141710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sec23a

Protein Name

SEC23A (S. cerevisiae)

Synonyms

Msec23; Sec23r;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021375

InnateDB Gene

IDBG-141708 (Sec23a)

Protein Structure

UniProt Annotation

Function

Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity). {ECO:0000250}.

Subcellular Localization

Smooth endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=In the ribosome-free transitional face of the ER and associated vesicles.

Disease Associations

Tissue Specificity

High levels in brain and fibroblasts.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0030127	COPII vesicle coat
GO:0030134	ER to Golgi transport vesicle
GO:0030868	smooth endoplasmic reticulum membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1349635

InterPro

IPR002035 von Willebrand factor, type A
IPR006895 Zinc finger, Sec23/Sec24-type
IPR006896 Sec23/Sec24, trunk domain
IPR006900 Sec23/Sec24, helical domain
IPR007123 Gelsolin-like domain
IPR012990 Sec23/Sec24 beta-sandwich

PFAM

PF00092
PF04810
PF04811
PF04815
PF00626
PF08033

PRINTS

PIRSF

SMART

SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q01405